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The Billon 2025 paper introducing SLU-PP-915 (PMID 41421047) describes the parent compound SLU-PP-332 as lacking oral bioavailability — the orally active sibling SLU-PP-915 was developed because of that limitation

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Pawlak and others reviewed studies of B12 deficiency among vegetarians and vegans using serum B12 (Pawlak, 2014) as well as methylmalonic acid and holotranscobalamin (Pawlak, 2013)